Target Region

Rodent Sex

Number for Behavior

Total for low range

∑ = 310

Total for high range

∑ = 610

Behavior

Methodology

Observe Before Perturb?

Comprehensive Data Table

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Target region:

Animal Model:

Strain:

Sex:

n for behavior – low range:

n for behavior – high range:

Behavior:

Methodology:

Virus:

Stimulation pattern or CNO dose:

Impact on anxiety behaviors:

Impact on fear behaviors:

Impact on depressive behaviors:

Reference:

Lab name:

PMID (PubMed ID):

Other behaviors run?:

Post-hoc confirmation of injections:

Observe before perturb?:

wdt_ID	Target region	Animal Model	Strain	Sex	n for behavior – low range	n for behavior – high range	Behavior	Methodology	Virus	Stimulation pattern or CNO dose	Impact on anxiety behaviors	Impact on fear behaviors	Impact on depressive behaviors	Reference	Lab name	PMID (PubMed ID)	Other behaviors run?	Post-hoc confirmation of injections	Observe before perturb?
1	mPFC	Mice	C57	Male	6	10	Chronic social defeat	Optogenetics	HSV-ChR2-mCherry, in HSVPrpUC,using the ChR2-mCherry DNA construct or mCherry alone (control)	ChR2 @ 40 ms 100 Hz light pulses every 3 seconds over the duration of each behavioral test	No change Open field test		Photostimulation of mPFC reverses depression-like symptoms in mice susceptible to social defeat	Covington et al., 2010	Eric J. Nestler	21.123.555		Yes, IEG expression run, p	Yes
2							Social interaction
3							Sucrose preference test
4	LA pyramidal neurons	Rats	Sprague-Dawley	Male	8	8	Fear conditioning	Optogenetics	AAV-CaMKII-GFP, pAAV-MCS, pAAV-CaMKII-ChR2/EYFP	CaMKII-ChR2 in LA @ 20-Hz, 10 ms pulse stimulation		Pairing an auditory cue with optical stimulation (no shock US) increased freezing/produced fear conditioning		Johansen et al., 2010	Joseph E. LeDoux	20.615.999		Yes, noted was confirmed	Yes
5	dCA1	Mice	C57	Unknown	4	6	Fear conditioning	Optogenetics	AAV-CaMKIIa-eNpHR3.0-EYFP, using BamHI and EcoRI restriction sites, AAV CaMKIIa::eNpHR3.0 and Lenti CaMKIIa::eNpHR3.1	CaMKIIα-eNpHR3.1 @ continuous light	No difference in Open field test	Photoinhibition during training prevents contextual fear memory/no effect recall. Photoinhibition during recall prevents fear recall		Goshen et al., 2011	Karl Deisseroth	22.019.004		Yes, when validated optogenetic activation found a significant increase in ACC neuronal activity in control mice, which was abolished in mice expressing eNpHR3.0 in ACC	No
6							Open field test
7	ACC	Mice	C57	Unknown	4	6	Fear conditioning	Optogenetics	AAV-CaMKIIa-eNpHR3.0-EYFP, using BamHI and EcoRI restriction sites, AAV CaMKIIa::eNpHR3.0 and Lenti CaMKIIa::eNpHR3.1	CaMKIIα-eNpHR3.1 @ continuous light	No difference in Open field test	Photoinhibition prevents long term fear recall (one month later)		Goshen et al., 2011	Karl Deisseroth	22.019.004		Yes, when validated optogenetic activation found a significant increase in ACC neuronal activity in control mice, which was abolished in mice expressing eNpHR3.0 in ACC	No
8							Open field test
9	DG	Mice	c-fos-tTA, TetTag, C57BL/6J	Unknown	5	12	Fear conditioning	Optogenetics	AAV9-TRE-ChR2-EYFP	Optogenetic reactivation of neurons activated during fear conditioning with c-fos-tTA transgenic mice + TRE-ChR2 + removal of DOX during training @ 20Hz trains during light-on (3 min off-on-off-on)		Optogenetic reactivation induces freezing behavior		Liu et al., 2012	Susumu Tonegawa	22.441.246		Yes, histologically verified	Yes
10	mPFC	Rats	Long-Evans	Male	8	16	Forced swim test	Optogenetics	pAAV-CaMKIIα∷hChR2(H134R)-eYFP, pAAV-CaMKIIα∷eYFP, pAAVCaMKIIα∷eNpHR3.0-eYFP, and pAAV-hSyn∷hChR2(H134R)-eYFP into mPFC or DRN	CaMKIIα-ChR2 with fiber over DRN or LhB @ pulse trains with 5 ms long 473 nm light pulses at 20 Hz	No effect in Open field test		No effect in forced swim test	Warden et al., 2012	Karl Deisseroth	23.160.494		Yes, IHC and optical microscopic confirmation, staining for DAPI and either rabbit anti-5-HT or rabbit anti-GABA	No
	Target region	Animal Model	Strain	Sex	n for behavior – low range	n for behavior – high range	Behavior	Methodology	Virus	Stimulation pattern or CNO dose	Impact on anxiety behaviors	Impact on fear behaviors	Impact on depressive behaviors	Reference	Lab name	PMID (PubMed ID)	Other behaviors run?	Post-hoc confirmation of injections	Observe before perturb?